Immune Sera Haemolysins, Cytotoxins, and Precipitins

Leukocyte antibodies in human sera and in immune rabbit sera.

Prevention of staphylococcal bacteriophage activity by antigen A precipitins in human sera.

Antigen A precipitins in human sera prevented plaque formation and propagation of staphylococcal bacteriophages. Over 20% of total IgG was removed from human sera by absorption with staphylococci containing antigen A. The specific precipitating antibody in rabbit antisera formed lines of idenity with antigen A precipitins in lower dilutions of human sera but formed lines of nonidenity with anti...

Poliovirus Precipitins

Antigens present in poliovirus concentrates react with antibodies present in the serum of hyperimmunized monkeys to give type-specific precipitates. One or more bands of precipitate can be formed wherever such homotypic reactants, diffusing into an agar gel, meet in sufficient concentration and in equivalent proportions. No qualitative differences have been detected between the type-specific re...

Specificity of Agglutinins and Precipitins

The knowledge of serological reactions has opened a field of research dealing with the specific configurations existing in the chemical constituents of organisms. The results of agglutinin and lysin reactions and the use of the absorption method have disclosed an unexpected variety of structures as exemplified by the existence of differently reacting groups in a single kind of cells, of differe...

Apoptosis and cytotoxins.

Most xenobiotics ultimately become lethally cytotoxic, according to concentration. Toxins with completely disparate mechanisms of action induce apoptotic cell death. This suggests that the threshold for the onset of cell death can be determined by the relative expression levels of genes which promote or suppress apoptosis. The selectivity of a toxin may thus be determined not only by the select...